3-(Pyrrolidin-1-ylmethyl)thiomorpholine → HCID 18915117, 화합물

HRID 1493159노트

반응식

HRID 1493159 반응식
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[CH:19]([C:23](Cl)=[O:24])[CH2:18][C:17]2=[O:26]>C(N(CC)CC)C>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[CH:19]([C:23]([N:8]1[CH2:9][CH2:10][S:11][CH2:12][CH:7]1[CH2:6][N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:24])[CH2:18][C:17]2=[O:26]

참가 물질

4

반응물 2

HCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholineHCID 18915111HCID 18915111, 화합물

생성물 1

HCID 18915117HCID 18915117, 화합물수율 67.7%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The procedure described in Example 24 was repeated, but using 3.7 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 3.42 ml of triethylamine and 4.56 g of 5-chloro-3-oxoindan-1-carbonyl chloride, to afford 2.8 g of the title compound, melting at 200°-205° C. (dec.).

출처 및 근거

ORD 기록
ord-ea15d2dca34741329e28beb616c6d75b
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021413

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