Methyl isothiocyanate → N-Methyl-N'-[2-[[3-(N,N-dimethylaminomethyl)phenyl]methylthio]ethyl]thiourea

HRID 1493184노트

반응식

HRID 1493184 반응식
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH2:15])[CH:8]=[CH:9][CH:10]=1)[CH3:3].[CH3:16][N:17]=[C:18]=[S:19]>C(#N)C>[CH3:16][NH:17][C:18]([NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH2:4][N:2]([CH3:1])[CH3:3])[CH:6]=1)=[S:19]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 129520192-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine

생성물 1

HCID 86744815N-Methyl-N'-[2-[[3-(N,N-dimethylaminomethyl)phenyl]methylthio]ethyl]thiourea

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-[[3-(N,N-Dimethylaminomethyl)phenyl]methylthio]ethanamine (5 g) and methyl isothiocyanate (1.62 g) were stirred at room temperature in acetonitrile for 18 hours. The solvent was removed and the residue was column chromatographed on silica using a mixture of ethyl acetate and methanol as eluent to give the title compound as a pale yellow oil. TLC silica; ethyl acetate:isopropanol:water:0.88 ammonia (25:15:8:2) Rf 0.61.

후처리

  1. customThe solvent was removed
  2. customchromatographed on silica using
  3. additiona mixture of ethyl acetate and methanol as eluent

출처 및 근거

ORD 기록
ord-04f5ef278ce147c68455c782963f3a1d
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021429

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