N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDE → HCID 14801070, 화합물

HRID 1493199노트

반응식

HRID 1493199 반응식
Cl[CH2:2][N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Cl)=[O:5].[Cl:13][C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][C:29]=1[Cl:30])[CH2:17][NH:18][C:19]([NH:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[S:20]>C1C=CC=CC=1>[F:26][C:23]([F:24])([F:25])[CH2:22][N:21]=[C:19]1[N:18]([CH2:17][C:16]2[CH:27]=[CH:28][C:29]([Cl:30])=[C:14]([Cl:13])[CH:15]=2)[C:4](=[O:5])[N:3]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:2][S:20]1

참가 물질

4

반응물 2

HCID 11241146N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDEHCID 14801046HCID 14801046, 화합물

생성물 1

HCID 14801070HCID 14801070, 화합물수율 40.2%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

1.00 g of N-chloromethyl-N-phenylcarbamoyl chloride and 1.55 g of 1-(3,4-dichlorobenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 m1 of benzene, and the solution was heated under reflux. After the reaction, benzene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography silica gel; eluent: hexane/ethyl acetate (10/1)] to give 0.88 g of the captioned compound.

후처리

  1. temperaturethe solution was heated
  2. temperatureunder reflux
  3. customwas evaporated under reduced pressure
  4. customThe resulting oily product was purified by column chromatography silica gel

출처 및 근거

ORD 기록
ord-822bce15d72446bc9e3832e14ff70787
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021412

반응 노트

불러오는 중…