1-(4-Difluoromethoxybenzyl)-3-(2,2,2-trifluoroethyl)thiourea → 2-(2,2,2-Trifluoroethylimino)-3(4-difluoromethoxybenzyl)-5-(4-methylphenyl)-tetrahydro-1,3,5-thiadiazin-4-one
반응식
Cl[CH2:2][N:3]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)[C:4](Cl)=[O:5].[F:14][CH:15]([F:33])[O:16][C:17]1[CH:32]=[CH:31][C:20]([CH2:21][NH:22][C:23]([NH:25][CH2:26][C:27]([F:30])([F:29])[F:28])=[S:24])=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[F:28][C:27]([F:29])([F:30])[CH2:26][N:25]=[C:23]1[N:22]([CH2:21][C:20]2[CH:31]=[CH:32][C:17]([O:16][CH:15]([F:14])[F:33])=[CH:18][CH:19]=2)[C:4](=[O:5])[N:3]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[CH2:2][S:24]1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
0.69 g of N-chloromethyl-N-(4-methylphenyl)carbamoyl chloride and 1.00 g of 1-(4-difluoromethoxybenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 ml of toluene, and the solution was heated under reflux for 4 hours. After the reaction, toluene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography silica gel; developing solvent hexane/ethyl acetate (10:1)]to give 0.80 g of the captioned compound.