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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1493426생성일: 2026년 10월 26일

Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl- → 2-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenone

https://huagongshe.com/reaction/1493426

반응식

참여 물질

역할이름HCID투입량
반응물Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl-HCID 13118721—
반응물4-Butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidineHCID 21182129—
용매EthanolHCID 702—
생성물2-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenoneHCID 1983135692%

반응 단계

A mixture of 4.0 g (14.8 g mmol) of 2-hydroxy-4-(2,3-epoxypropoxy)benzophenone, 6.9 g (22.2 mmol) of 4-butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine, and 40 ml of ethanol is heated at reflux for 4 hours. Ethanol is evaporated, and the residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate) to afford 7.9 g (92% yield) of the title compound, a yellow oil.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05021478
출처 데이터셋uspto-grants-1991_06
ORD IDord-a570d021a0e74516a4da3eca9e2dd342
출처 메모uspto-grants-1991_06