Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl- → 2-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl- | HCID 13118721 | — |
| 반응물 | 4-Butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine | HCID 21182129 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenone | HCID 19831356 | 92% |
반응 단계
A mixture of 4.0 g (14.8 g mmol) of 2-hydroxy-4-(2,3-epoxypropoxy)benzophenone, 6.9 g (22.2 mmol) of 4-butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine, and 40 ml of ethanol is heated at reflux for 4 hours. Ethanol is evaporated, and the residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate) to afford 7.9 g (92% yield) of the title compound, a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05021478 |
| 출처 데이터셋 | uspto-grants-1991_06 |
| ORD ID | ord-a570d021a0e74516a4da3eca9e2dd342 |
| 출처 메모 | uspto-grants-1991_06 |