Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Pyridineethanamine → (4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-pyridin-4-yl-ethyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Pyridineethanamine | HCID 83275 | — |
| 반응물 | 4-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603290 | — |
| 생성물 | (4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-pyridin-4-yl-ethyl)-amine | HCID 58603626 | — |
반응 단계
Intermediate 84 was coupled with 2-Pyridin-4-yl-ethylamine following procedure F. The resulting product was deprotected following procedure G. LC-MS showed the product had the expected M+H+ of 417. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.30 ppm) δ 8.72 (d, 2H) 88.3-8.5 (m, 2H) 8.06 (d, 2H) 7.88 (d, 1H) 7.72 (m, 1H) 7.58 (d, 1H) 4.59 (d, 2H) 4.12 (br s, 2H) 3.85 (m, 1H) 3.62 (m, 2H) 3.1-3.45 (m, 6H) 2.48 (m, 2H) 2.18-2.24 (m, 2H) 1.35 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6409b96ed3a441848571294cacaf00f3 |
| 출처 메모 | uspto-grants-2010_06 |