Nitric Acid → 3-Nitro-4-chloro-benzoyl-propionic acid

반응식

[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[O:7])=[CH:4][CH:3]=1.[N+:15]([O-])([OH:17])=[O:16]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[O:7])=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 189171154-Chlorobenzoylpropionic acid

생성물 1

HCID 189171033-Nitro-4-chloro-benzoyl-propionic acid

반응 조건

온도: 0 °C

실험 절차

To fuming nitric acid (150 ml) was added p-chlorobenzoylpropionic acid (20.0 g), slowly portionwise at 0° C. After the addition was completed the resulting mixture was stirred at 0° C. for 30 minutes and the resulting white solid was suction filtered and washed with water until the pH of the washing liquids was neutral, then dried to yield 3-(4-chloro-3-nitrobenzoyl)propionic add as a white solid (13.0 g).

후처리

customslowly portionwise at 0° C
additionAfter the addition
filtrationthe resulting white solid was suction filtered
washwashed with water until the pH of the washing liquids
customdried
customto yield 3-(4-chloro-3-nitrobenzoyl)propionic

출처 및 근거

ORD 기록: ord-853ac2ea43e24e448317811edbddc04c
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05726162

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