Beta-Alanine → 3-[(2-Nitrophenyl)amino]propanoic acid
반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15].C(N(CC)CC)C.O>CN(C)C=O>[C:14]([CH2:13][CH2:12][NH:11][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9])([OH:16])=[O:15]참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 5.0 g (36 mmol) 2-fluoronitrobenzen, 6.3 g (71 mmol) β-alanin, 20 ml triethylamine, 50 ml water and 100 ml dimethylformamide was stirred at 80° C. for 10 h After cooling to 25° C. the reaction mixture was evaporated in vacuo. The residue was stirred with 1N hydrochloric acid, and the precipitate was filtered off and washed with water to give 3.6 g (48%) N- carboxyethyl-2-nitroaniline. M.p. 145° C., 1H-NMR (DMSO-d6): 8.2-6.2 (5H, m), 3.4 (2H, q), 2.5 (2H, t).
후처리
- temperatureAfter cooling to 25° C. the reaction mixture
- customwas evaporated in vacuo
- stirringThe residue was stirred with 1N hydrochloric acid
- filtrationthe precipitate was filtered off
- washwashed with water
출처 및 근거
- ORD 기록
- ord-5c1d3296164a4952b7849da1d69435f6
- 출처 데이터셋
- uspto-grants-1991_06
- 특허 번호
- US05026704
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