Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butyl bromide → N-butyl-N-acetyl-2,4-difluoroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butyl bromide | HCID 8002 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Acetamide, N-(2,4-difluorophenyl)- | HCID 96093 | — |
| 촉매 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-butyl-N-acetyl-2,4-difluoroaniline | HCID 19827549 | 68.7% |
반응 단계
0.9 g of triethylbenzylammonium chloride, 6.9 g of butyl bromide and a solution of 5.7 g of KOH in 6 ml of water are added to a stirred solution of 3.4 g of N-acetyl-2,4-difluoroaniline (Example 2) in 60 ml of toluene. The emulsion produced is warmed at 97° (reflux). After 1 h, the emulsion is cooled to room temperature and diluted with 20 ml of water. The two phases are separated, and the organic phase is dried over MgSO4 and evaporated in vacuo. The liquid crude product is purified by medium-pressure chromatography. 3.1 g of N-butyl-N-acetyl-2,4-difluoroaniline are obtained as a brownish oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05026625 |
| 출처 데이터셋 | uspto-grants-1991_06 |
| ORD ID | ord-97ddca6efec049b8af0e4bcb966496bc |
| 출처 메모 | uspto-grants-1991_06 |