Thionyl Chloride → HCID 15087728, 화합물

HRID 1494640노트

반응식

HRID 1494640 반응식
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:11]=[CH:10][C:9](/[C:12](/[C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[CH:13]\[CH2:14][CH2:15][CH2:16]O)=[CH:8][CH:7]=1>>[Cl:3][CH2:16][CH2:15][CH2:14]/[CH:13]=[C:12](/[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)\[C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 15087804HCID 15087804, 화합물

생성물 1

HCID 15087728HCID 15087728, 화합물수율 94.4%

실험 절차

160 Parts of thionyl chloride were added dropwise to 10 parts of (E)-5-(4-fluorophenyl)-5-(3-pyridinyl)-4-penten-1-ol while stirring (exothermic reaction, the temperature rose to 45° C.). Upon complete addition, stirring was continued for 2 hours at room temperature. The reaction mixture was evaporated. The residue was taken up in methylbenzene and the solvent was evaporated again. The residue was solidified in 2,2'-oxybixpropane. The product was filtered off and dried, yielding 11.5 parts (94.4%) of (E)-3-[5-chloro-1-(4-fluorophenyl)-1-pentenyl]pyridine hdyrochloride (int. 60).

후처리

  1. customexothermic reaction
  2. customrose to 45° C.
  3. additionUpon complete addition
  4. stirringstirring
  5. customThe reaction mixture was evaporated
  6. customthe solvent was evaporated again
  7. filtrationThe product was filtered off
  8. customdried

출처 및 근거

ORD 기록
ord-228e13040b974a43ad57c2c02e88fcb8
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05026853

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