Sodium Sulfate → 2-Benzyl-4-hydroxymethylisoindoline

HRID 1494846노트

반응식

HRID 1494846 반응식
[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[C:17](OC)=[O:18])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH2:1]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH2:17][OH:18])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 24436Sodium SulfateHCID 19828480Methyl 2-benzylisoindoline-4-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 198285052-Benzyl-4-hydroxymethylisoindoline수율 73.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

8.02 g of 2-benzyl-4-methoxycarbonylisoindoline was dissolved in 20 ml of anhydrous tetrahydrofuran and to the solution was added 1.9 g of lithium aluminum hydride. After stirring for 20 hours at room temperature, an aqueous solution of sodium sulfate was added. Insoluble materials were removed by filtration, the filtrate was concentrated, and the residue was recrystallized from ether to give 5.27 g of 2-benzyl-4-hydroxymethylisoindoline.

후처리

  1. customInsoluble materials were removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customthe residue was recrystallized from ether

출처 및 근거

ORD 기록
ord-d3612332c92c44609cd395b0ff479db7
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05026856

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