Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 반응물 | 5-Formyl-2-methoxyphenylboronic acid | HCID 2734367 | — |
| 생성물 | 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde | HCID 24901876 | 70% |
반응 단계
2,4 dichloropyrimidine and 5-formyl-2-methoxyphenylboronic acid was coupled following procedure A. The yield was 70%. LC-MS showed the product was >95% pure and had the expected M+H+ of 249. 1H NMR (Varian 300 MHz, MeOD-d6, shifts relative to the solvent peak at 3.33 ppm) δ 9.9 (s, 1H) 8.7 (d, 1H) 8.4 (s, 1H) 8.0 (d, 2H) 7.4 (d, 1H) 3.9 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4ce789c572b7461498d343a62c43931b |
| 출처 메모 | uspto-grants-2010_06 |