HCID 90383149, 화합물 → 4-(4-Acetyl-piperazin-1-YL)-2-chloroaniline
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>C(O)C>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)=[CH:3][C:2]=1[Cl:1]참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
The compound prepared in Step 1 was dissolved in ethanol (10 ml) and distilled water (1.0 ml), added with iron (powder, 2.0 g) and ammonium chloride (1.0 g), and stirred at 90° C. for 2 hours. Then, the resultant was filtered using celite and the filtrate was distilled under reduced pressure to remove the solvent. The resulting white solid was used in the subsequent reaction without further purification.
후처리
- distillationdistilled water (1.0 ml)
- additionadded with iron (powder, 2.0 g) and ammonium chloride (1.0 g)
- filtrationThen, the resultant was filtered
- distillationthe filtrate was distilled under reduced pressure
- customto remove the solvent
- customThe resulting white solid was used in the subsequent reaction without further purification
출처 및 근거
- ORD 기록
- ord-ba5414df8f934728aa66e9826a823895
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09199944B2
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