Dimethylformamide → 3-Bromo-5-fluorobenzoyl chloride
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5](O)=[O:6].CN(C=O)C.C(Cl)(=O)C([Cl:20])=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([Cl:20])=[O:6]참가 물질
5
실험 절차
10 g of 3-bromo-5-fluoro-benzoic acid are suspended in 100 ml of DCM, 0.5 ml DMF and 4.5 ml oxalyl chloride (1.15 Eq) are added and the resulting mixture is stirred for 100 minutes at RT. The solvent is removed by vacuo and the benzoic acid chloride is isolated by distillation.
후처리
- customThe solvent is removed by vacuo
출처 및 근거
- ORD 기록
- ord-66fa69f971064cbe863bd8e0e91ff497
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09199947B2
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