Methyl malonyl chloride → HCID 86682941, 화합물

HRID 1497074노트

반응식

HRID 1497074 반응식
Cl[C:2](=[O:8])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[NH2:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=1[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>C(Cl)Cl>[CH3:7][O:6][C:4](=[O:5])[CH2:3][C:2]([NH:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:8]

참가 물질

4

반응물 2

HCID 123460Methyl malonyl chlorideHCID 12516780(2-Amino-3,5-dichlorophenyl)(phenyl)methanone

생성물 1

HCID 86682941HCID 86682941, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 3-chloro-3-oxopropanoate (317 mg, 249 μl, 2.25 mmol, Eq: 1.2) was added dropwise to a yellow solution of (2-amino-3,5-dichloro-phenyl)-phenyl-methanone (500 mg, 1.88 mmol, Eq: 1.00) in DCM (5 ml) at 0° C. The yellow solution was then allowed to warm slowly to RT. After completion of the reaction the mixture was washed with sat. NaHCO3 solution and brine, dried with Na2SO4 and evaporated. The remaining light brown residue (603 mg) was used in the next reaction step without further purification. MS (ESI): 366.0 (M+H)+.

후처리

  1. customAfter completion of the reaction the mixture
  2. washwas washed with sat. NaHCO3 solution and brine
  3. dry with materialdried with Na2SO4
  4. customevaporated
  5. customThe remaining light brown residue (603 mg) was used in the next reaction step without further purification

출처 및 근거

ORD 기록
ord-998d4d5658704a9da0232698b0de309b
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199938B2

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