Ethyl 3-chloro-3-oxopropionate → N-[4-Chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenyl]-malonamic acid ethyl ester

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([NH2:9])=[C:4]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[CH:3]=1.[CH2:19]([O:21][C:22](=[O:27])[CH2:23][C:24](Cl)=[O:25])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:27])[CH2:23][C:24]([NH:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=1[C:10]#[C:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])=[O:25])[CH3:20]

참가 물질

반응물 2

HCID 118931Ethyl 3-chloro-3-oxopropionate

HCID 86682981HCID 86682981, 화합물

생성물 1

HCID 86682982N-[4-Chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenyl]-malonamic acid ethyl ester

실험 절차

The title compound was prepared in analogy to example 29 step A from 4-chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenylamine (570 mg, 2.03 mmol) and chlorocarbonyl-acetic acid ethyl ester (460 mg, 3.05 mmol). White solid (440 mg, 55%) MS (ESI): 394 (M+H)+.

출처 및 근거

ORD 기록: ord-20ff7d2bb77c474b85f54dec96ab7585
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09199938B2

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