(2-Amino-5-chlorophenyl)(3-chlorophenyl)methanone → 6-Chloro-4-(3-chloro-phenyl)-2-isopropyl-quinoline-3-carbonitrile

HRID 1497257노트

반응식

HRID 1497257 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=O.[CH3:18][CH:19]([CH3:25])[C:20](=O)[CH2:21][C:22]#[N:23]>>[Cl:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:20]([CH:19]([CH3:25])[CH3:18])[C:21]([C:22]#[N:23])=[C:9]2[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1

참가 물질

3

반응물 2

HCID 5231029(2-Amino-5-chlorophenyl)(3-chlorophenyl)methanoneHCID 101299214-Methyl-3-oxopentanenitrile

생성물 1

HCID 866830736-Chloro-4-(3-chloro-phenyl)-2-isopropyl-quinoline-3-carbonitrile

실험 절차

The title compound was prepared in analogy to example 101 step B from (2-amino-5-chloro-phenyl)-(3-chloro-phenyl)-methanone (prepared as described in example 91 step A) and 4-methyl-3-oxo-pentanenitrile. Light yellow solid. MS (ESI): 341.3 (M+H)+.

출처 및 근거

ORD 기록
ord-f05cedb8ac3a436685a32b3f73ded915
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199938B2

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