Cesium fluoride → HCID 89350931, 화합물

HRID 1497314노트

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HRID 1497314 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[F:17])[CH:5]=[C:4]([Cl:18])[N:3]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[N:25][CH:26]=1.[F-].[Cs+]>O1CCOCC1.O>[Cl:18][C:4]1[N:3]=[C:2]([C:23]2[CH:24]=[N:25][CH:26]=[C:21]([C:20]([F:31])([F:30])[F:19])[CH:22]=2)[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[F:17])[CH:5]=1

참가 물질

5

반응물 3

HCID 25953Cesium fluorideHCID 45158900[5-(Trifluoromethyl)pyridin-3-yl]boronic acidHCID 89350889(2,6-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-benzyl)-amine

생성물 1

HCID 89350931HCID 89350931, 화합물

시약·촉매·용매 1

HCID 218864351,4-Dioxane--water (1/1)용매

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온도
60 °C

실험 절차

A mixture of (2,6-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-benzyl)-amine (1 g, 0.0034 mol) and 5-trifluoromethylpyridine-3-boronic acid (0.726 g, 0.0038 mol) were taken in dioxane:water (20:5) ml and to this CsF (2.1 g, 0.0138 mol) was added and degassed. Then bis-triphenylphosphine-palladium(II) chloride (0.24 g, 0.00034 mol) was added and degassed. The mixture was stirred at 60° C. for 12 hrs. The reaction was cooled to room temperature diluted with water (50 ml) and ethyl acetate (100 ml). After standard work-up, the residue was purified by column chromatography to get compound as white solid.

후처리

  1. customdegassed
  2. customdegassed
  3. temperatureThe reaction was cooled to room temperature
  4. additiondiluted with water (50 ml) and ethyl acetate (100 ml)
  5. customAfter standard work-up, the residue was purified by column chromatography
  6. customto get compound as white solid

출처 및 근거

ORD 기록
ord-5f6a859c98cb4b198eebfdd35b5928bc
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199962B2

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