Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol | HCID 20079604 | — |
| 생성물 | 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole | HCID 17750414 | 60.7% |
반응 단계
Thionyl chloride (4.89 g) was added to [2-(trifluoromethyl)thiazol-4-yl]methanol (512 mg) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated to give the title compound (342 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09199963B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-c6f91f438ef24adf9d0a6d6db989878b |
| 출처 메모 | uspto-grants-2015_12 |