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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1497632생성일: 2026년 10월 24일

2-(Methylsulfonyl)ethanamine → N-[4-(benzyloxy)phenyl]-6-[4-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

https://huagongshe.com/reaction/1497632

반응식

참여 물질

역할이름HCID투입량
반응물2-(Methylsulfonyl)ethanamineHCID 4340561—
반응물5-(4-{4-Benzyloxyanilino}-6-quinazolinyl)-furan-3-carbaldehydeHCID 21952275—
생성물N-[4-(benzyloxy)phenyl]-6-[4-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamineHCID 9828335—

반응 단계

Prepared according to Procedure D from 5-(4-{4-benzyloxyanilino}-6-quinazolinyl)-furan-3-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR 400 MHz, d6DMSO 9.51 (bs, 2H), 9.11 (s, 1H), 8.79 (s, 1H), 8.29 (d, 1H), 8.06 (s, 1H), 7.90 (d, 1H), 7.60 (d, 2H), 7.5-7.3 (m, 5H), 7.11 (d, 2H), 5.14 (s, 2H), 4.14 (bs, 2H), 3.6-3.5 (m, 3H), 3.12 (s, 3H); MS m/z 529 (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09199973B2
출처 데이터셋uspto-grants-2015_12
ORD IDord-cfc44fecc66d4facb03a25a69c02477c
출처 메모uspto-grants-2015_12