(2-Amino-5-bromophenyl)(4-chlorophenyl)methanone → 2-Methyl-propane-2-sulfinic acid (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)-methyleneamide

HRID 1497713노트

반응식

HRID 1497713 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=O.[CH3:18][C:19]([S:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>C1COCC1>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=[N:24][S:22]([C:19]([CH3:21])([CH3:20])[CH3:18])=[O:23]

참가 물질

4

반응물 2

HCID 182477(2-Amino-5-bromophenyl)(4-chlorophenyl)methanoneHCID 3382465Tert-Butanesulfinamide

생성물 1

HCID 1234860542-Methyl-propane-2-sulfinic acid (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)-methyleneamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

To a solution of (2-Amino-5-bromo-phenyl)-(4-chloro-phenyl)-methanone (13.87 g, 0.05 mol) in THF (200 mL) is added 2-Methyl-propane-2-sulfinic acid amide (6.5 g, 0.05 mol) and Ti(OEt)4 (20.5 g, 0.09 mol).The stirred mixture is refluxed at 80° C. The mixture is quenched with H2O, filtered. THF is removed, extracted with ethyl acetate, dried over NaSO4 and concentrated then purified by silica gel. This produces the desired compound.

후처리

  1. customThe mixture is quenched with H2O
  2. filtrationfiltered
  3. customTHF is removed
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over NaSO4
  6. concentrationconcentrated
  7. customthen purified by silica gel

출처 및 근거

ORD 기록
ord-b1e1fe71f526430e872375e4ddd15dbb
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199988B2

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