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1,2-Dimethoxyethane → HCID 86273822, 화합물

HRID 1497741
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HRID 1497741 반응식
[CH3:1][N:2]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]2[C:5](=[CH:6][CH:7]=[C:8](B3OC(C)(C)C(C)(C)O3)[CH:9]=2)[NH:4][C:3]1=[O:27].I[C:29]1[C:30]([O:35][CH3:36])=[N:31][O:32][C:33]=1[CH3:34].C(=O)([O-])[O-].[K+].[K+].C(COC)OC>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O>[CH3:36][O:35][C:30]1[C:29]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[NH:4][C:3](=[O:27])[N:2]([CH3:1])[CH:11]3[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:33]([CH3:34])[O:32][N:31]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 80711,2-DimethoxyethaneHCID 11430Potassium CarbonateHCID 117600656HCID 117600656, 화합물HCID 123205558HCID 123205558, 화합물

생성물 1

HCID 86273822HCID 86273822, 화합물

시약·촉매·용매 2

HCID 44119782
Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)
촉매
HCID 962Water용매

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온도
120 °C

실험 절차

3-Methyl-4-phenyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinazolin-2-one (457 mg, 1.255 mmol), 4-Iodo-3-methoxy-5-methyl-isoxazole (150 mg, 0.628 mmol), potassium carbonate (173 mg, 1.255 mmol) and Pd(dppf)Cl2 (102.5 mg, 0.126 mmol) are added to a microwave vessel. Dimethoxyethane (0.1 mL) and water (0.1 mL) are added and the vessel flushed with argon. The mixture is heated in a microwave reactor at 120° C. for 3.5 hours. The reaction mixture is extracted with ethyl acetate from water. The organic phase is dried over Na2SO4 and the solvent is removed on a rotary evaporator. The residue is purified by reversed phase HPLC.

후처리

  1. customthe vessel flushed with argon
  2. extractionThe reaction mixture is extracted with ethyl acetate from water
  3. dry with materialThe organic phase is dried over Na2SO4
  4. customthe solvent is removed on a rotary evaporator
  5. customThe residue is purified by reversed phase HPLC

출처 및 근거

ORD 기록
ord-deb3e23ded1d484290e8d4b34fc01b9e
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09199988B2

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