Chlorotrimethylsilane → HCID 178462437, 화합물

HRID 1498832노트

반응식

HRID 1498832 반응식
[Zn:1].[Br:2]CCBr.Cl[Si](C)(C)C.Br[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:13]>C1COCC1>[Br-:2].[C:14]1([CH:12]([Zn+:1])[CH3:13])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 11454(1-Bromoethyl)benzeneHCID 23994Zinc

생성물 1

HCID 178462437HCID 178462437, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension mixture of zinc powder (active, 5.1 g, 80.0 mmol) in dry THF (20 mL) was added dropwise 1,2-dibromoethane (0.28 mL, 5.7 mmol) at 70° C. under nitrogen atmosphere, followed by the addition of chlorotrimethylsilane (1.2 mL, 10.6 mmol). Subsequently, (1-bromoethyl)benzene (3.7 g, 20 mmol) was added dropwise. The resultant suspension was stirred at 70° C. for another 1 h. The reaction mixture was cooled to RT and directly used for the next step.

출처 및 근거

ORD 기록
ord-ce6132e4c18f4c558fc8ddc0776c7a96
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09200002B2

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