Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-chloroacetoacetate → Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| 반응물 | 2,4-Dichlorobenzenecarbothioamide | HCID 2734822 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate | HCID 58657933 | 64% |
반응 단계
In ethanol (10 ml), 2,4-dichlorothiobenzamide (378 mg) was dissolved, and ethyl 2-chloroacetoacetate (302 mg) was added thereto. The mixture was heated under reflux for 25 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration, washed with water, and dried to give ethyl 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylate (368 mg, 64%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09200008B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-750a4e1c9298490da065ea5e7c3488a9 |
| 출처 메모 | uspto-grants-2015_12 |