Hydrazine hydrate (1:1) → HCID 68642532, 화합물

HRID 1498933

반응식

HRID 1498933 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([O:17]CC)=O)=[C:12]([CH3:14])[N:13]=1.O.[NH2:21][NH2:22]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([NH:21][NH2:22])=[O:17])=[C:12]([CH3:14])[N:13]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 58657933Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 68642532HCID 68642532, 화합물수율 88.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylate (250 mg) prepared in the Step 23-1-1 was dissolved in ethanol (10 ml), and hydrazine monohydrate (794 mg) was added thereto. The mixture was heated under reflux for 23 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration, washed with water, and dried to give 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylic acid hydrazide (211 mg, 88%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 23 hours
  3. temperatureto cool
  4. customthe precipitated crystal was separated by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-8094eb14aecd4fe688b54e3ac0a66359
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09200008B2

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