3,5-Dimethyl-4-hydroxybenzaldehyde → 4-{[1-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethylidene]hydrazonomethyl}-2,6-dimethyl-phenol
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:14](=[N:16][NH2:17])[CH3:15])=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[OH:18][C:19]1[C:26]([CH3:27])=[CH:25][C:22]([CH:23]=O)=[CH:21][C:20]=1[CH3:28]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([C:14](=[N:16][N:17]=[CH:23][C:22]3[CH:25]=[C:26]([CH3:27])[C:19]([OH:18])=[C:20]([CH3:28])[CH:21]=3)[CH3:15])=[C:11]([CH3:13])[N:12]=2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
In ethanol (3 ml), {1-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethylidene}-hydrazine (40 mg) prepared in the Step 30-1-2 and 4-hydroxy-3,5-dimethylbenzaldehyde (29 mg) was heated under reflux for 20 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration to give the title compound (23 mg, 38%).