홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → 2-Benzyl 3-ethyl 8-(4-amino-6-((naphthalen-2-ylmethyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

HRID 1499208
노트
인쇄 미리보기

반응식

HRID 1499208 반응식
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([N:9]2[CH2:33][CH2:32][C:12]3([CH2:16][N:15]([C:17]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:18])[CH:14]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:13]3)[CH2:11][CH2:10]2)[N:3]=1.[CH:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:37]=[CH:36][C:35]=1[CH2:44][NH2:45].CCN(CC)CC>C(O)(C)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:45][CH2:44][C:35]2[CH:36]=[CH:37][C:38]3[C:43](=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH:34]=2)[N:5]=[C:4]([N:9]2[CH2:33][CH2:32][C:12]3([CH2:16][N:15]([C:17]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:18])[CH:14]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:13]3)[CH2:11][CH2:10]2)[N:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1372821-(2-Naphthyl)methanamineHCID 1179478002-Benzyl 3-ethyl 8-(4-amino-6-chloro-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

생성물 1

HCID 1179427132-Benzyl 3-ethyl 8-(4-amino-6-((naphthalen-2-ylmethyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

시약·촉매·용매 1

HCID 3776
Isopropanol
용매

실험 절차

To a solution of 2-benzyl 3-ethyl 8-(4-amino-6-chloro-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate (265 mg, 0.56 mmol) in isopropanol (3 mL) were added naphthalen-2-ylmethanamine (105 mg, 0.67 mmol) and Et3N (1.4 mL). The reaction mixture was heated to reflux for 12 h, then cooled to RT, and concentrated in vacuo. Purification by normal phase chromatography (CH2Cl2/MeOH) provided 2-benzyl 3-ethyl 8-(4-amino-6-((naphthalen-2-ylmethyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate as a white solid.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 12 h
  3. concentrationconcentrated in vacuo
  4. customPurification by normal phase chromatography (CH2Cl2/MeOH)

출처 및 근거

ORD 기록
ord-f4c9d0b2ff09458988c28a9901b4e817
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09199994B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트