Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine → N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| 반응물 | methyl (1S)-3-oxocyclopentane-1-carboxylate | HCID 13827616 | — |
| 반응물 | Ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate | HCID 59340971 | — |
| 반응물 | (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane | HCID 67237087 | — |
| 생성물 | N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide | HCID 86637550 | — |
반응 단계
Analogously to Example 1 and Example 36, ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate, (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane (prepared analogously to Example 40 from commercially available methyl (S)-3-oxo-cyclopentanecarboxylate) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732440B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-21acdf692c1a49009e3af8ed3e8a6972 |
| 출처 메모 | uspto-grants-2010_06 |