1-Aminocyclopentanecarboxamide → 1-((2-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenoxy)ethyl)amino)cyclopentanecarboxamide

HRID 1499310

반응식

CN(C)CC(C)(C)CNC[CH2:8][CH2:9][O:10][C:11]1[CH:35]=[CH:34][C:14]([CH2:15][C:16]2[CH:17]=[C:18]([C@H:23]3[C@H:28]([OH:29])[C@@H:27]([OH:30])[C@H:26]([OH:31])[C@@H:25]([S:32][CH3:33])[O:24]3)[CH:19]=[CH:20][C:21]=2[CH3:22])=[CH:13][CH:12]=1.[NH2:39][C:40]1([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH3:22][C:21]1[CH:20]=[CH:19][C:18]([C@H:23]2[C@H:28]([OH:29])[C@@H:27]([OH:30])[C@H:26]([OH:31])[C@@H:25]([S:32][CH3:33])[O:24]2)=[CH:17][C:16]=1[CH2:15][C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][NH:39][C:40]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43][CH2:42][CH2:41]2)=[CH:35][CH:34]=1

참가 물질

반응물 2

HCID 111160861-Aminocyclopentanecarboxamide

HCID 90183140(2S,3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimethylamino)-2,2-dimethylpropyl)amino) propoxy)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol

생성물 1

HCID 901830811-((2-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenoxy)ethyl)amino)cyclopentanecarboxamide

실험 절차

The same procedure was employed as for amine 50, using 1-aminocyclopentanecarboxamide, to provide the product 52. 1H NMR (400 MHz, MeOH-d4) δ ppm 7.11-7.21 (m, 3 H), 7.06 (d, J=8.3 Hz, 2 H), 6.85 (m, J=8.6 Hz, 2 H), 4.39 (d, J=9.6 Hz, 1H), 4.12 (d, J=9.3 Hz, 1 H), 4.06 (t, J=4.9 Hz, 2 H), 3.94 (s, 2 H), 3.34-3.54 (m, 3 H), 2.92 (t, J=4.8 Hz, 2 H), 2.20 (s, 3 H), 2.14 (s, 3 H), 2.06-2.13 (m, 2 H), 1.75-1.83 (m, 6 H); MS (ES+) [M+H]+=531.

출처 및 근거

ORD 기록: ord-1f9162e52a7f439eb886ce8a75ab38ca
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09200025B2

연결된 노트

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