Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodide Ion → 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodide Ion | HCID 30165 | — |
| 반응물 | Ethyl-4,4-difluorocyclohexane carboxylate | HCID 2779138 | — |
| 반응물 | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| 반응물 | tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate | HCID 59340981 | — |
| 반응물 | 1,1-Difluoro-4-(iodomethyl)cyclohexane | HCID 67236985 | — |
| 생성물 | 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide | HCID 58024254 | — |
반응 단계
Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732440B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-3958a078b667471db485796a4948a9a2 |
| 출처 메모 | uspto-grants-2010_06 |