Diphenyl N-Cyanocarbonimidate → HCID 178512234, 화합물

HRID 1500352노트

반응식

HRID 1500352 반응식
[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][CH:13]([NH:16]C(OC(C)(C)C)=O)[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2].C1C=CC(OC(OC2C=CC=CC=2)=NC#N)=CC=1>C(O)(C)C.[H][H].[Pd]>[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2]

참가 물질

5

반응물 2

HCID 688090Diphenyl N-CyanocarbonimidateHCID 178452634HCID 178452634, 화합물

생성물 1

HCID 178512234HCID 178512234, 화합물

시약·촉매·용매 2

HCID 178506449HCID 178506449, 화합물촉매HCID 3776Isopropanol용매

실험 절차

The single enantiomer was then BOC-protected, the nitro group reduced by treatment with H2/Pd and the primary aniline treated with diphenyl cyanocarbonimidate (slight excess) in 20 mL of isopropanol with stirring at ambient temperature overnight. The solid was filtered, washed with isopropanol and ether and dried to give phenyl (7S)—N′-cyano-N-(7-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate, as a white solid in high yield (from the single enantiomer via transamination).

후처리

  1. filtrationThe solid was filtered
  2. washwashed with isopropanol and ether
  3. customdried

출처 및 근거

ORD 기록
ord-bac8a748b96c477a93855a46d68e18da
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206161B2

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