2-(Isopropylthio)aniline → N-(2-(isopropylthio)phenyl)-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 1500457노트

반응식

HRID 1500457 반응식
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]2[NH:10][N:11]=[C:12]([CH3:13])[C:3]=12.[CH:14]([S:17][C:18]1[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=1[NH2:20])([CH3:16])[CH3:15]>C(O)(C)C>[CH:14]([S:17][C:18]1[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=1[NH:20][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]2[NH:10][N:11]=[C:12]([CH3:13])[C:3]=12)([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 138527202-(Isopropylthio)anilineHCID 1785034684-Chloro-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

생성물 1

HCID 178503488N-(2-(isopropylthio)phenyl)-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 4-chloro-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine (A-3) (1.21 g, 5.63 mmol) and 2-(isopropylthio)aniline (A-4) (1.42 g, 8.50 mmol) in isopropanol (56 mL) was stirred at reflux for 3 h. After cooling down to ambient temperature, TEA (0.78 mL, 5.66 mmol) was added to the mixture, and the solution was again heated to reflux for 0.5 h. After cooling down to ambient temperature, the mixture was filtered to give the title compound (A-5) as white solid (1.30 g, 3.77 mmol). MS-ESI (m/z): 346 (M+H)+.

후처리

  1. temperatureat reflux for 3 h
  2. temperaturethe solution was again heated
  3. temperatureto reflux for 0.5 h
  4. temperatureAfter cooling down to ambient temperature
  5. filtrationthe mixture was filtered

출처 및 근거

ORD 기록
ord-dd303b6baf284962a61fa365e36357c6
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206166B2

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