HCID 86718008, 화합물 → HCID 86718009, 화합물

HRID 1500471노트

반응식

HRID 1500471 반응식
[CH3:1][C@@H:2]1[CH2:6][C:5]2[CH:7]=[C:8]([CH3:14])[CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1>C1COCC1.[Pd]>[CH3:1][C@@H:2]1[CH2:6][C:5]2[CH:7]=[C:8]([CH3:14])[CH:9]=[C:10]([NH2:11])[C:4]=2[O:3]1

참가 물질

4

반응물 1

HCID 86718008HCID 86718008, 화합물

생성물 1

HCID 86718009HCID 86718009, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

The mixture of (R)-2,5-dimethyl-7-nitro-2,3-dihydrobenzofuran (3e) (0.84 g, 4.3 mmol) and Pd/C (100 mg, 15%) in THF (10 mL) was introduced H2 at ambient temperature. It was stirred at ambient temperature for 12 h. The mixture was filtered through Celite and concentrated to give the title compound (3f) as a solid. MS-ESI (m/z): 164 (M+1)+.

후처리

  1. additionwas introduced H2 at ambient temperature
  2. filtrationThe mixture was filtered through Celite
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a1152d0534f648f7977fa159ea8673db
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206166B2

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