Pyrimidine, 2-ethynyl-4-methoxy- (9CI) → HCID 71743828, 화합물

반응식

[F:1][C:2]1[C:3]([O:14][CH3:15])=[N:4][C:5]([C:8]#[C:9][Si](C)(C)C)=[N:6][CH:7]=1.C(C1N=C(OC)C=CN=1)#C>>[C:8]([C:5]1[N:4]=[C:3]([O:14][CH3:15])[C:2]([F:1])=[CH:7][N:6]=1)#[CH:9]

참가 물질

반응물 2

HCID 10011938Pyrimidine, 2-ethynyl-4-methoxy- (9CI)

HCID 67327167HCID 67327167, 화합물

생성물 1

HCID 71743828HCID 71743828, 화합물

실험 절차

Obtained (82%) from 5-fluoro-4-methoxy-2-((trimethylsilyl)ethynyl)pyrimidine (Preparation 16b) following the experimental procedure as described in Preparation 1b followed by purification by flash chromatography (99:1 dichloromethane/methanol).

후처리

customfollowed by purification by flash chromatography (99:1 dichloromethane/methanol)

출처 및 근거

ORD 기록: ord-8478145a147f4cda96e93b0888abb220
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09206183B2

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