2-Oxa-5-azaspiro[3.4]octane-5-carboxylic acid, 7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester → Tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate

HRID 1500927노트

반응식

HRID 1500927 반응식
C(OC([NH:11][CH:12]1[CH2:19][C:15]2([CH2:18][O:17][CH2:16]2)[N:14]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:13]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][CH:12]1[CH2:19][C:15]2([CH2:16][O:17][CH2:18]2)[N:14]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:13]1

참가 물질

4

반응물 1

HCID 899238142-Oxa-5-azaspiro[3.4]octane-5-carboxylic acid, 7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

생성물 1

HCID 89924062Tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate수율 96.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of tert-butyl 7-{[(benzyloxy)carbonyl]amino}-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (566 mg, 1.56 mmol) in 20 mL of MeOH was stirred with 10% Pd/C (100 mg) under hydrogen atmosphere at room temperature for 50 minutes. The resulting mixture was filtered and the filtration was concentrated in vacuo to afford tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (343 mg, yield: 96.3%) as light viscous oil.

후처리

  1. filtrationThe resulting mixture was filtered
  2. filtrationthe filtration
  3. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-a3dfc268d2894ff79f1608cd6ff1d536
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206191B2

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