Water → 2-Bromo-1-benzofuran

HRID 1501076

반응식

HRID 1501076 반응식
[Br:1][C:2](Br)=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].P([O-])([O-])([O-])=O.[K+].[K+].[K+].O>O1CCCC1.[Cu]I>[Br:1][C:2]1[O:10][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 62657Potassium Phosphate, TribasicHCID 99936722-(2,2-Dibromovinyl)phenol

생성물 1

HCID 27762642-Bromo-1-benzofuran수율 92%

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-(2,2-dibromovinyl)phenol (2.8 g, 10 mmol) in tetrahydrofuran (30 mL) was added copper (I) iodide (0.1 g, 0.5 mmol) and potassium phosphate (4.2 g, 20 mmol). The reaction mixture was stirred at 80° C. under nitrogen atmosphere for 12 hours. After the reaction, the mixture was poured into water (200 mL) and the mixture was extracted with ethyl acetate (200 mL). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20) to give the pure product 2-bromobenzofuran (1.8 g, 92%).

후처리

  1. customAfter the reaction
  2. extractionthe mixture was extracted with ethyl acetate (200 mL)
  3. dry with materialThe organic phase was dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated
  6. customthe residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20)

출처 및 근거

ORD 기록
ord-8489cbb7f6b945b39df28733c1ae5143
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206128B2

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