Cesium carbonate → HCID 89582703, 화합물

HRID 1501095

반응식

HRID 1501095 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](Br)[CH3:9])=[CH:4][CH:3]=1.[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]2=[O:17])[CH3:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 98381461-Bromo-4-(1-bromoethyl)benzeneHCID 178516071HCID 178516071, 화합물

생성물 1

HCID 89582703HCID 89582703, 화합물수율 76.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1-bromo-4-(1-bromoethyl)benzene (200 mg, 0.76 mmol) and pyridin-2-ol (87 mg, 0.91 mmol) in N,N-dimethylformamide (30 mL) was added cesium carbonate (496 mg, 1.52 mmol). The mixture was stirred at room temperature for 12 hours. And then solvent was removed to give a residue. The residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:10) to give 1-(1-(4-bromophenyl)ethyl)pyridin-2(1H)-one (161 mg, 76%) LRMS (M+H+) m/z: calcd 277.0. found 277.

후처리

  1. customAnd then solvent was removed
  2. customto give a residue
  3. customThe residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:10)

출처 및 근거

ORD 기록
ord-54c9556da1bd4b8985fad085b5c6dc87
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206128B2

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