HCID 89581294, 화합물 → HCID 89580553, 화합물
반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:18]=[CH:17][C:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[CH:8][CH:7]=1>CO.[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]1[CH:18]=[CH:17][C:9]([C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])=[CH:8][CH:7]=1참가 물질
4
실험 절차
To a solution of tert-butyl 4-(furan-2-yl)benzoate (400 mg, 1.64 mmol) in methanol (20 mL) was added palladium on carbon (10%, 100 mg). After stirring for 24 hours at room temperature under hydrogen atmosphere, the mixture was filtered. And the filtrate was concentrated in vacuo to give tert-butyl 4-(tetrahydrofuran-2-yl)benzoate (350 mg, 86%) as a white solid. LRMS (M+H+) m/z: calcd 248.14. found 248. 1H NMR (300 MHz, CD3OD): δ 7.94-7.85 (m, 2H), 7.44-7.28 (m, 2H), 4.95-4.93 (m, 1H), 3.60-3.56 (m, 2H), 2.73-2.68 (m, 2H), 1.77-1.73 (m, 2H), 1.68 (s, 9H).