참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | 1-(4-Bromo-3-fluorophenyl)ethan-1-ol | HCID 71756542 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Bromo-2-fluoro-4-(1-phenoxyethyl)benzene | HCID 118562734 | 89% |
반응 단계
A solution of 1-(4-bromo-3-fluorophenyl)ethanol (1 g, 4.58 mmol), phenol (474 mg, 4.58 mmol), and triphenyl phosphine (2.4 g, 6.88 mmol) was stirred in dry tetrahydrofuran (40 mL) under nitrogen atmosphere. After 1 h, the mixture was cooled to 0° C. Diisopropyl azodicarboxylate (2.3 g, 6.88 mmol) was added with drop-wise method and the reaction was stirred at room temperature for 18 hours. The solvent was evaporated and the residue was purified by column chromatography (silica gel, petroleum ether) to get 1-bromo-2-fluoro-4-(1-phenoxyethyl)benzene (900 mg, 89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09206128B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_12 |
|---|
| ORD ID | ord-c1269fa2f8c147b7a8ad9d876f1f5c61 |
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| 출처 메모 | uspto-grants-2015_12 |
|---|
