Nitric Acid → 5-Chloro-2-methyl-3-nitrobenzoic acid

HRID 1501695

반응식

HRID 1501695 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[N+:12]([O-])([OH:14])=[O:13]>OS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 820095-Chloro-2-methylbenzoic acid

생성물 1

HCID 230097625-Chloro-2-methyl-3-nitrobenzoic acid수율 60%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

A stirred solution of 5-chloro-2-methylbenzoic acid (1 mmol) in conc. H2SO4 (2 mL) was cooled to −10° C. and nitrating mixture (0.4 mL of conc. H2SO4+0.1 mL of conc. HNO3) was added to it in dropwise manner. The reaction mixture was stirred at the same temperature for 20 min then warmed to room temperature. The solid precipitate was filtered and dried to obtain 5-chloro-2-methyl-3-nitrobenzoic acid which was used in next step without further purification (yield 60-70%).

후처리

  1. filtrationThe solid precipitate was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-bfab7be9238c446b8970d45b2006cf49
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206157B2

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