Boron tribromide → 2,6-Difluoro-3-hydroxybenzonitrile

HRID 1502009노트

반응식

HRID 1502009 반응식
[F:1][C:2]1[C:9]([O:10]C)=[CH:8][CH:7]=[C:6]([F:12])[C:3]=1[C:4]#[N:5].B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([F:12])[C:3]=1[C:4]#[N:5]

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 37918322,6-Difluoro-3-methoxybenzonitrile

생성물 1

HCID 451191012,6-Difluoro-3-hydroxybenzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2,6-difluoro-3-methoxybenzonitrile (4.42 g, 26.1 mmol) was dissolved in DCM (10 mL) at 0° C. then 1 M BBr3 (52.2 mL, 52.2 mmol) was added. The reaction mixture was then warmed up to RT and stirred overnight. The reaction mixture was poured into ice water and extracted with more DCM. The organic layer was separated, dried over Na2SO4, filtered, and evaporated to dryness to yield 2,6-difluoro-3-hydroxybenzonitrile: LC-MS: M+1=156.

후처리

  1. extractionextracted with more DCM
  2. customThe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-8c287bd2ca46486b80208d0799ea52f3
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206199B2

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