5-Bromo-4-methylpyridine-3-carbonitrile → 5-Ethenyl-4-methylpyridine-3-carbonitrile
반응식
Br[C:2]1[C:3]([CH3:10])=[C:4]([C:8]#[N:9])[CH:5]=[N:6][CH:7]=1.[CH:11]([B-](F)(F)F)=[CH2:12].[K+]>CCO>[CH:11]([C:2]1[C:3]([CH3:10])=[C:4]([C:8]#[N:9])[CH:5]=[N:6][CH:7]=1)=[CH2:12]참가 물질
4
실험 절차
A mixture of 5-bromo-4-methylpyridine-3-carbonitrile (4.40 g, 22.3 mmol), potassium vinyltrifluoroborate (3.70 g, 27.9 mmol) and Pd (dppf)2Cl2 (0.4 g) in 30 mL of EtOH and 30 mL of TEA was refluxed under Ar for 4 hours. Concentrated, the residue was purified by column chromatography (petrol ether: EtOAc=50:1) to afford 5-ethenyl-4-methylpyridine-3-carbonitrile.
후처리
- temperaturewas refluxed under Ar for 4 hours
- concentrationConcentrated
- customthe residue was purified by column chromatography (petrol ether: EtOAc=50:1)
출처 및 근거
- ORD 기록
- ord-7445b1458bd54f859535ba0994ba61c8
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09206199B2
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