m-Chloroperbenzoic acid → 5-(Oxiran-2-yl)-2,1,3-benzoxadiazole
반응식
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]2=[N:7][O:8][N:9]=[C:5]2[CH:4]=1)=[CH2:2].C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[O:20]1[CH2:2][CH:1]1[C:3]1[CH:11]=[CH:10][C:6]2=[N:7][O:8][N:9]=[C:5]2[CH:4]=1참가 물질
4
실험 절차
To a solution of 5-ethenyl-2,1,3-benzoxadiazole (1.80 g, 12.3 mmol) in DCM (20 mL) was slowly added m-CPBA (3.8 g, 22 mmol) at 0° C. The flask was warmed to room temperature; the mixture was then stirred for 12 hours. TLC as well as LC indicated that reaction had gone to completion. The mixture was washed with aqueous Na2S2O3, NaHCO3, and water. The organic layers was washed with brine and then concentrated. The residue was purified over silica gel to afford the title compound.
후처리
- customat 0° C
- customTLC as well as LC indicated that reaction
- washThe mixture was washed with aqueous Na2S2O3, NaHCO3, and water
- washThe organic layers was washed with brine
- concentrationconcentrated
- customThe residue was purified over silica gel
출처 및 근거
- ORD 기록
- ord-9b1e90322f5a456fb9af78d4c1cf850a
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09206199B2
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