Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1-Dimethylethyl (trans)-3-hydroxy4-[[(phenylmethyl)amino]methyl]-1-piperidinecarboxylate → trans-1-Boc-4-aminomethyl-3-hydroxypiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1-Dimethylethyl (trans)-3-hydroxy4-[[(phenylmethyl)amino]methyl]-1-piperidinecarboxylate | HCID 11738727 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | trans-1-Boc-4-aminomethyl-3-hydroxypiperidine | HCID 11075229 | 72.9% |
반응 단계
A mixture of intermediate (43) (0.028 mol) in methanol (100 ml) was hydrogenated with palladium-on-carbon (10%, 2 g) as a catalyst. After uptake of hydrogen (1 equivalent) the catalyst was filtered off and the filtrate was evaporated, yielding 4.7 g of 1,1-dimethylethyl (3S-trans)-4-(aminomethyl)-3-hydroxy-1-piperidinecarboxylate (intermediate (44); [α]D20=+4.37° (c=24.03 mg/5 ml in CH3OH)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732464B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-215187a38156403f81f9176d9ddfd99e |
| 출처 메모 | uspto-grants-2010_06 |