Sodium Sulfite → 4-Bromo-2,5-dimethylpyridine 1-oxide

HRID 1502350노트

반응식

HRID 1502350 반응식
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][N:5]=[C:4]([CH3:9])[CH:3]=1.ClC1C=CC=C(C(OO)=[O:18])C=1.C(=O)(O)[O-].[Na+].S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][N+:5]([O-:18])=[C:4]([CH3:9])[CH:3]=1

참가 물질

6

반응물 4

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 223175304-Bromo-2,5-dimethylpyridine

생성물 1

HCID 544438594-Bromo-2,5-dimethylpyridine 1-oxide수율 76%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Bromo-2,5-dimethylpyridine (500 mg, 2.69 mmol) was added dropwise to a solution of m-chloroperbenzoic acid (816 mg, 3.55 mmol) in dichloromethane (10 mL) at ambient temperature. The mixture was stirred at room temperature for 17 hours, poured into saturated aqueous sodium bicarbonate and sodium sulfite (2 mL, 1.0M), and extracted twice into ethyl acetate. The combined organic phases were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford a yellow crystralline solid (413 mg) which was used without further purification. LCMS: M+H+=202 & 204.

후처리

  1. extractionextracted twice into ethyl acetate
  2. washThe combined organic phases were washed with brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cdf8e6fd579d44f6b119adc5b69cc513
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206175B2

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