Ethyl trifluoroacetate → 2,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

HRID 1502522노트

반응식

HRID 1502522 반응식
[NH:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4].[F:8][C:9]([F:16])([F:15])[C:10](OCC)=[O:11]>C1COCC1>[F:8][C:9]([F:16])([F:15])[C:10]([N:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4])=[O:11]

참가 물질

4

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 640091L-Prolinol2회

생성물 1

HCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매4회

실험 절차

L-prolinol (2.0 g, 20 mmol) was dissolved in 20 ml of THF. On the other hand, ethyl trifluoroacetate (3.0 g, 21 mmol) was dissolved in 20 ml of THF. Then, the latter THF solution was instilled in the former THF solution containing the L-prolinol, and this was stirred for 12 hours. This reaction solution was vacuum concentrated. Thus, Compound 1 was obtained (3.7 g, yield: 97%). The result of NMR analysis with respect to this compound is shown below.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8dbac55ae9e14f62ac2fa353941ec212
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206422B2

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