참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 5-Bromo-3-hydroxyisoindolin-1-one | HCID 11615537 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-Bromophthalazin-1(2h)-one | HCID 11535918 | — |
반응 단계
To a stirred solution of 5-bromo-3-hydroxyisoindoline-1-one (1.0 g, 4.40 mmol) in water, was added hydrazine hydrate (0.45 g, 8.80 mmol) and heated to 95° C. for 5 h. The reaction mixture was cooled to ambient temperature, filtered and washed with diethyl ether and pentane (1:1) to afford the title compound as a white solid that was used in the next step without further purification (0.5 g): ESIMS m/z 225.15 ([M+H]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09210927B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_12 |
|---|
| ORD ID | ord-2798d879d6b9437090dd4a923629b71e |
|---|
| 출처 메모 | uspto-grants-2015_12 |
|---|
