N-methylpropionohydrazide → (E)-2-Bromo-N'-methyl-N'-propionyl-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzohydrazide

참여 물질

역할	이름	HCID	투입량
반응물	N-methylpropionohydrazide	HCID 542680	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
반응물	(E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid	HCID 86722549	—
촉매	4-(Dimethylamino)pyridine	HCID 14284	—
용매	1,2-Dichloroethane	HCID 11	—
생성물	(E)-2-Bromo-N'-methyl-N'-propionyl-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzohydrazide	HCID 86722548	—

반응 단계

Prophetically, (E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid can be reacted with N-methylpropionohydrazide in the presence of N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride (EDC.HCl) and DMAP in 1,2-dichloroethane (DCE) to furnish the title molecule (Org. Lett. 2004, 6, 929-931).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09211280B2
출처 데이터셋	uspto-grants-2015_12
ORD ID	ord-6c428054ce2e49a3a56a1acc4690526c
출처 메모	uspto-grants-2015_12