2-Methoxyaniline → 4-methoxy-N-(2-methoxyphenyl)benzenesulfonamide

HRID 1503084

반응식

HRID 1503084 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH3:13][O:14][C:15]1[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=1[NH2:17].C(N(CC)CC)C>ClCCl>[CH3:13][O:14][C:15]1[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=1[NH:17][S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10]

참가 물질

5

반응물 3

HCID 70002-MethoxyanilineHCID 74014-Methoxybenzenesulfonyl chlorideHCID 8471Triethylamine

생성물 1

HCID 7434174-methoxy-N-(2-methoxyphenyl)benzenesulfonamide수율 75.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-methoxybenzenesulfonyl chloride (5.0 g, 24 mmol) and 2-methoxyaniline (3.0 g, 24 mmol) in dichloromethane (24 mL) at 0° C. was added triethylamine (3.4 mL, 24 mmol) over 10 minutes. The ice bath was removed, and the mixture was stirred for 16 hr. The mixture was diluted with dichloromethane (100 mL) and the combined solution was washed with water (50 mL) and brine (50 mL). The organic solution was dried over MgSO4, filtered, and evaporated, and the crude product was purified by silica gel chromatography (15-60% EtOAc/Hex). Product-containing fractions were pooled, evaporated, and dried under high vacuum to yield 5.3 g (44%) of the product as a tan-colored oil: 1H-NMR (CDCl3) δ 7.70-7.67 (d, 2H), 7.53-7.50 (d, 1H), 7.05-6.99 (m, 2H), 6.91-6.83 (m, 3H), 6.73 (d, 1H), 3.80 (s, 3H), 3.65 (s, 3H).

후처리

  1. customThe ice bath was removed
  2. additionThe mixture was diluted with dichloromethane (100 mL)
  3. washthe combined solution was washed with water (50 mL) and brine (50 mL)
  4. dry with materialThe organic solution was dried over MgSO4
  5. filtrationfiltered
  6. customevaporated
  7. customthe crude product was purified by silica gel chromatography (15-60% EtOAc/Hex)
  8. customevaporated
  9. customdried under high vacuum

출처 및 근거

ORD 기록
ord-27558dc9d9c345b6819f96b64c294c61
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212134B2

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