N-methylpropyn-2-ylamine → Benzyl 2-(3-(methyl(prop-2-ynyl)amino)oxetan-3-yl)acetate

HRID 1503304노트

반응식

HRID 1503304 반응식
[CH3:1][NH:2][CH2:3][C:4]#[CH:5].[O:6]1[CH2:9][C:8](=[CH:10][C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:7]1>>[CH3:1][N:2]([CH2:3][C:4]#[CH:5])[C:8]1([CH2:10][C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:7][O:6][CH2:9]1

참가 물질

3

반응물 2

HCID 96160N-methylpropyn-2-ylamineHCID 54759148Benzyl (oxetan-3-ylidene)acetate

생성물 1

HCID 86663091Benzyl 2-(3-(methyl(prop-2-ynyl)amino)oxetan-3-yl)acetate

실험 절차

A mixture of N-methyl-propargylamine (0.27 g) and benzyl 2-(oxetan-3-ylidene)acetate (0.41 g) was stirred neat at RT for 12 h. The excess amine was removed by evaporation to give benzyl 2-(3-(methyl(prop-2-ynyl)amino)oxetan-3-yl)acetate quantitatively (0.54 g).

후처리

  1. customThe excess amine was removed by evaporation

출처 및 근거

ORD 기록
ord-2412ee43c72e4dc59f52343124b808f4
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212175B2

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